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Combining Private Enterprise

with Academic Excellence

The Toxicology Reserach Laboratory offers drug metabolism and pharmacokinetic (DMPK) studies in support of drug candidate selection or regulatory submission. Based on specific goals our skilled in-vitro and in-vivo ADME scientists, together with our pharmacokineticists have the ability to design and interpret both in-vitro and in-vivo components of your drug metabolism studies.  The PK parameters assessed include AUC, half-life, volume of distribution, bioavailability, AUC, Cmax, Tmax, first order rate constant for absorption, terminal elimination rate constant; clearance, volume of distribution, and bioavailability. We have experience with a number of dose routes, including intravenous (IV), oral (PO), transdermal, intra-peritoneal (IP), intra-muscular (IM), subcutaneous (SC) etc, depending on the specific design and objective of the study.

Following studies are offered

         -  Custom-designed ADME studies in multiple species of laboratory animals

         -  Drug kinetics in plasma

         -  Quantitative tissue distribution of drug

         -  Metabolic profiling of drug using animal and human microsomes, S9 and hepatocytes

Metabolism Distribution