Vortex © 2012 Privacy Policy

Combining Private Enterprise

with Academic Excellence

 

 

 

 

Stokvis E., Nan-Offeringa L, Rosing H, Lopez-Lazaro L, Acena J. L., Miranda E., Lyubimov A.V., Levine B.S., D'Aleo C, Schellens J. H, Beijnen J. H.,  Stokvis E.,  D’Aleo, C.  Quantitative analysis of ES-285, an investigational marine anticancer drug in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.  J. of Mass Spectrometry, 2003, 38:548-554. PMID: 12794877

 

Lyubimov A.V., Smith J. D., Rousselle S., Mercieca M. D., Tomaszewski J. E., Smith A. C., Levine  B.S. The effects of tetrathiomolybdate and copper supplementation on fertility and early embryonic development in rats.  Reproductive Toxicology, 2004, 19:223-233. PMID: 15501388

 

Beggs K.J., Lyubimov A.V., Borneman J.N., Bartholomew A., Moseley A., Dodds R., Archambault M.P., Smith A.K., and McIntosh K.R.  Immunologic consequences of multiple, high-dose administration of allogeneic mesenchymal stem cells to baboons.  Cell Transplantation: The Regenerative Medicine Journal. 2006, 15:711-721.  PMID: 17269442

 

Lyubimov A.V., Mercieca M.D., Tomaszewski J.E., Smith A.C. and Levine B.S.  The developmental toxicity of tetrathiomolybdate and protective effects of copper in rats.  Submitted to Toxicological Sciences.

 

Lyubimov A.V., Carr S., Crowell J., Levine B.S. Evaluation of Hydrogen Ion Concentrations in Prostate from Rats and Dogs.  Journal of Photochemistry & Photobiology, B: Biology, 2005, 80:225-234. PMID: 15982897

 

Lyubimov A.V., Mercieca M.D., Tomaszewski J.E., Smith A.C., and Levine B.S.  The embryotoxicity and teratogenicity of tetrathiomolybdate and protective effects of copper in rabbits.  In preparation.

 

Holleran J.L., Parise R.A., Joseph E., Eiseman J.L., Covey J.M., Glaze E.R., Lyubimov A.V., Chen Y-F., D’Argenio D.Z., and Egorin M.J.  Plasma pharmacokinetics, oral bioavailability, and interspecies sealing of the DNA methyltransferase inhibitor, zebularine (NSC 309132), in mice, rats, and rhesus monkeys.  Clinical Cancer Research, 2005, 11(10):3862-3868. PMID: 15897587

 

Kalin T.V., I-Ching Wang, Ackerson T.J., Major M.L., Detrisac C., Kalinichenko V.V, Lyubimov A.V., and Costa R.H. Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice. Cancer Research, 2006, 66 (3):1-10. PMID: 16452231

 

Kapetanovic I .M., Krishnaraj R.,  Martin-Jiminez, T., van Breemen R.B., Yuan L., and Lyubimov A.V. Effects of oral dosing paradigms (gavage vs. diet) on pharmacokinetics and pharmacodynamics. Chemico-Biological Interactions, 2006, 164: 68-75. PMID: 18992230

 

Lyubimov A.V., Kapetanovic I .M. Analytical Chemistry Methods- Developments and Validation. Book Chapter 5 in: Preclinical Drug Development Handbook.  Shayne C. Gad, Editor. John Willey &Sons Inc., 2008, 151-210.

 

Lyubimov A.V. and Bekerski I. Bioavialability and Bioequivalence Studies. Book Chapter 35. In: Preclinical Drug Development Handbook.  Shayne C. Gad, Editor. John Willey &Sons Inc. , 2008, 1069-1101.

 

Lyubimov A.V. Chapter 17: Dosage Formulation. Book Chapter in: Preclinical Drug Development Handbook.  Shayne C. Gad, Editor. John Willey &Sons Inc., 2008, 571-625.

 

Kabirov K.K., Kapetanovic I.M., and Lyubimov A.V. Direct Determination of Selenium in Rat Blood Plasma by Zeeman Atomic Absorption Spectrometry. Chemico-Biological Interactions, 2008, 171 (2):152-158. PMID: 18155186

 

Lyubimov A.V.  Editorial. Frontiers of Pharmacology and Toxicology. Translational research in cancer and developing medical countermeasures against radiation and infectious diseases threats. Chemico-Biological Interactions, 2008, 171 (2):117-121. PMID: 18177848

 

Martín-Jiménez T., Lindeblad M, Kapetanovic I.M., Chen Y., and Lyubimov A.V. Comparing pharmacokinetic and pharmacodynamic profiles in rats orally exposed to lovastatin by gavage vs. diet. Chemico-Biological Interactions, 2008, 171 (2):142-151. PMID: 17854789

 

Kapetanovic I.M, Crowell J.A., Krishnaraj R., Zakharov A., Lindeblad M., and Lyubimov A.V., Exposure and Toxicity Of Green Tea Polyphenols In Dogs. Toxicology, 2009, 260: 28-36. PMID: 19464566

 

Burgess J.P., Green J. S., Hill J. M., Zhan Q., Lindeblad M., Lyubimov A.V., Kapetanovic I. M., Schwartz A., and Thomas B.F. Identification of [14C]Fluasterone Metabolites in Urine and Feces Collected from Dogs following Subcutaneous and Oral Administration of [14C]Fluasterone, Drug Metabolism and Disposition,. 2009,37(5):1089-1097. PMID: 19196848

 

Kapetanovic I. M, Bauer K.,  Zakharov A,  Lindeblad M, Tessier D.,  Lyubimov A.V. Comparison of Pharmacokinetic and Pharmacodynamic Profiles of Aspirin Following Oral Gavage and Diet Dosing. Chemico-Biological Interactions, 2009,179, (2-3):233-239. PMID: 18992230

 

Kabirov K.K., Jackson J., Kapetanovic I., Lyubimov A.V., In Vitro Assessment of P-450 Induction Potential of Three Chemopreventive Agents in Primary Human Hepatocytes.  Chemico-Biological Interactions, 2009, 179, (2-3): 263-272. PMID: 19135037.

 

Lindeblad M., Kapetanovic I.M., Schwartz A., Bauer K, Thomas B., and Lyubimov A.V. Pharmacokinetic and tissue distribution study of 14C-Fluasterone in male Beagle dogs. Chemico-Biological Interactions, 2009;183(2):317-26. PMID: 19836365

 

Halasi M., Zhao H.,  Dahari H., Bhat U.G.,  Gonzalez E.B.,  Lyubimov A.V., Tonetti,  D.A., Gartel A.L. Thiazole antibiotics against breast cancer.  Cell Cycle, 2010. Cell Cycle. 15;9(6).PMID: 20410687.

 

Lyubimov A.V. and Garry V.F.  Phosphine. Chapter in: Handbook of Pesticide Toxicology. Volume 2. Third edition. Academic Press, San Diego, Chapter 104, 2010, 2259-2266.

 

Lindeblad M., Kapetanovic I.M., Kabirov K.K., Detrisac C.J., Dinger N., Mankovskaya I., Zakharov A., and Lyubimov A.V.,  Assessment of oral toxicity and safety of pentamethylchromanol (PMCol), a potential chemopreventative agent, in rats and dogs. Toxicology, 273, (1-3), 2010,  19-28. PMID: 20430063.

 

Lindeblad M., Kapetanovic I.M., Kabirov K.K., Dinger N., Mankovskaya I., Morrisey R., Martín-Jiménez T., Lyubimov A.V.  Assessment Of Oral Toxicity And Safety Of 9-Cis-UAB30, A Potential Chemopreventive Agent, In Rat And Dog Studies. Drug Chem Toxicol. 2011 Jul;34(3):300-10. PMID: 21649485.

 

Weidong Xu, Haixia Gong, Zakharov A., Jian Lu, Feng Qian, Krbanjevic A., Pavlovic S., Lyubimov A.V., Wang Z.J., Xiaoping Du. Importance of the platelet glycoprotein Ib-IX in LPS-induced microvascular thrombosis and a new strategy in treating endotoxemia. Blood. Submitted.

 

Reichstetter S.,, Castillo G.M., ManShun Lai, Nishimoto-Ashfield A., Jones C.C., Banerjee A., Lyubimov A.V., Bolotin E.M. Protected Graft Copolymer (PGC) basal formulation of insulin as potentially safer alternative to Lantus® (insulin-glargine): A streptozotocin-induced, diabetic Sprague Dawley rats study. Pharmaceutical research. 12/2011; 29(4):1033-1039. PMID: 22203325

 

Hao Shen, Banerjee A., Mlynarska P., Hautman M., Seungpyo Hong, Kapetanovic I.M., Lyubimov A.V., and Ying Liu. Enhanced oral bioavailability of a cancer preventive agent (SR13668) by employing polymeric nanoparticles with high drug loading.  Journal of Pharmaceutical Sciences, 2012; Volume 101 (10): 3553–4023.  

 

Kapetanovic I.M., Lyubimov A.V., Kabirova E.V., Kabirov K.K.,  Rasay L., Swezey R., and Green C., Kopelovich L.  Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chemico-Biological Interactions, 2012;197(1):16-22 . PMID: 22450444.

 

Banerjee A., Hao Shen, Hautman M., Anwer J., Kapetanovic I.M., Ying Liu, Lyubimov A.V. Polymeric Nanoparticles Enchance The Bioavailability Of The Chemopreventive Agent SR13668 In Beagle Dogs But Not In Monkeys. International Journal of Pharmaceutics. Submitted.

 

Ming Wang, Halasi M., Banerjee A., Landolfi J., Lyubimov A.V., and Gartel A.L. Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis. Cell Cycle, ACCEPTED 2012.

 

Nanomaker E., Lyubimov A.V., Fortman J. Predictive observation-based endpoint criteria for mice receiving total body irradiation. Comparative Medicine. Submitted.

 

Ming Wang, Marianna Halasi, Aryamitra Banerjee, Jennifer Landolfi, Aleksander V. Lyubimov and Andrei L. Gartel. Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis. Cell Cycle, 2012.

 

Nunamaker E., Anderson R.J., Artwohl J.E., Lyubimov A, Fortman J. D. Predictive observation-based endpoint criteria for mice receiving total body irradiation. Comparative Medicine, 2013;63(4):313-322.

 

Reichstetter S, Castillo GM, Rubinstein I, Nishimoto-Ashfield A, Lai M, Jones CC, Banjeree A, Lyubimov A, Bloedow DC, Bogdanov A Jr, Bolotin EM. Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles. Pharm Res. 2013 Mar;30(3):670-82. PMID: 23224976.

 

Kabirov, K.K., Kapetanovic, I.M., Benbrook, D.M., Dinger, N., Mankovskaya, I., Zakharov, A., Detrisac, C., Pereira, M., Martín-Jiménez, T., Onua, E., Banerjee, A., van Breemen, R.B., Nikolić, D., Chen, L., Lyubimov, A.V.  Oral Toxicity and Pharmacokinetic Studies of SHetA2, a New Chemopreventive Agent, in Rats and Dogs.  Drug and Chemical Toxicology.  2013 Jul;36(3):284-95. PMID: 22947079.

 

Aryamitra A. Banerjee, Hao Shen, Mathew Hautman, Jaseem Anwer, Izet M. Kapetanovic, Ying Liu, Alexander V. Lyubimov. Polymeric Nanoparticles Enchance The Bioavailability Of The Chemopreventive Agent SR13668 In Beagle Dogs. Curr Pharm Biotechnol. Curr Pharm Biotechnol. 2013 Mar;14(4):464-9. PMID: 23590143

 

Gerardo  M.  Castillo, Akiko  Nishimoto-Ashfield,    Aryamitra  A.  Banerjee,    Jennifer A.  Landolfi,     Alexander V.  Lyubimov, Elijah M. Bolotin. Omeprazole and PGC-formulated heparin binding Epydrmal Growth Factor normalizing fasting blood glucose and suppresses insulitis in multiple low dose streptozotocin diabetes model.  Pharm Research, 2013 Nov; 30(11): 2843-54. PMID: 23793991

 

Hong Yin, Aleksandra Stojanovic, Weidong Xu, Adam Corken, Alexander Zakharov, Feng Qian, Sasha Pavlovic, Aleksandar Krbanjevic, Alexander V Lyubimov, Zaijie J Wang, Jerry Ware, Xiaoping Du.  Role for Platelet Glycoprotein Ib-IX and Effects of Its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality. Arteriosclerosis Thrombosis and Vascular Biology: 09/2013; ACCEPTED

 

 

Publications