Combining Private Enterprise
with Academic Excellence
Welcome to our Laboratory
The Toxicology Research Laboratory has significant 30-year experience in preclinical safety and efficacy assessment programs. These include acute, subchronic, and chronic toxicity studies; reproductive and developmental toxicity studies; neurobehavioral toxicity studies; and pharmacokinetics, metabolism, and disposition studies. Expertise in neuropharmacology, cardiovascular and safety pharmacology testing is also available on-site.
The Toxicology Research Laboratory is fully computerized, and uses the LABCAT online data collection system for the capture of in-life, clinical pathology, organ weight, and histopathological data. This data collection system includes built-in statistical programs, which allows for immediate analysis of data (ANOVA, Dunnett's Test, Duncan's Multiple Range Procedure, Regression Analysis, etc). Additional statistical programs such as BMDP, SPSS, SAS, etc., are available in-house and utilized by our biostatisticians in the analysis of complex data sets.
Support services necessary for the conduct of safety assessment programs are available on site. These include a comprehensive, fully equipped analytical chemistry laboratory, veterinary pathology services, a boardcertified veterinary opthalmologist, a pharmacokineticist, and several biostatisticians. A consulting board-certified veterinary cardiologist is also available.
TRL's genomic and proteomic research is supported by the UIC Genomic core facility and Protein Research Laboratory. TRL is located in the middle of the "Illinois Medical District", surrounded by four major hospitals. This gives TRL a unique opportunity to continue preclinical safety studies in clinical trials.
Acute Radiation Models
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For over 15 years TRL has been on the forefront of basic model development and validation alongside their government and regulatory partners helping define expectations and guidelines for the pre-clinical evaluation of new and effective medical countermeasures for radiation injuries among the civilian population.