Toxicology Research Laboratory (TRL) brings over 30 years of expertise in preclinical translational research, specializing in toxicity, safety, and efficacy assessments.
As a leading research institution, TRL is uniquely positioned within a dynamic academic and industry ecosystem, offering state-of-the-art facilities and comprehensive support for drug development. Our multidisciplinary team—comprising industry experts and highly trained professionals—provides specialized technical and regulatory guidance to streamline the research and approval process.
Over the past three decades, UIC-TRL has fostered successful collaborations with government agencies and industry partners, contributing to the advancement of more than 100 compounds through various stages of clinical approval. Several of these therapeutics are now successfully marketed in the U.S. and worldwide.
At Toxicology Research Laboratory (TRL), we offer a full spectrum of preclinical testing programs, including acute, subchronic, and chronic toxicity studies; reproductive and developmental toxicity assessments; neurobehavioral toxicity evaluations; and pharmacokinetics, metabolism, and disposition studies.
Our specialized expertise extends to ophthalmic safety, neuropharmacology, and cardiovascular safety pharmacology testing, all available on-site.
TRL is equipped with a fully integrated analytical chemistry laboratory, complemented by on-site veterinary clinical and pathology services. Our team includes board-certified specialists in veterinary ophthalmology, cardiology, pharmacokinetics, and biostatistics, ensuring the highest standards in research execution and data analysis.
We leverage the capabilities of the UIC Genomic Core Facility and Protein Research Laboratory, enhancing our genomic and proteomic studies with world-class resources.
Situated within the Illinois Medical District and surrounded by four major hospitals, TRL is uniquely positioned to bridge preclinical research with clinical application, facilitating the seamless translation of safety studies into human trials.
With over 20 years of experience in radiation research, TRL serves as a valuable resource for government and industry-sponsored programs. Our facility features a hospital-based clinical linear accelerator, enabling advanced model development for radiation-based studies.
TRL utilizes electronic data capture with real-time online monitoring, ensuring efficient tracking of in-life events and rapid reporting for streamlined decision-making.
At TRL, we combine cutting-edge technology, expert guidance, and a collaborative research environment to support the success of your drug development programs.
As the Director of the Toxicology Research Laboratory, with over 27 years of experience in pharmacology, toxicology, and clinical pathology, Mr. Lindeblad brings extensive scientific and regulatory expertise to preclinical research and program oversight. Throughout his career, Mr. Lindeblad has authored more than 20 scientific publicatio
As the Director of the Toxicology Research Laboratory, with over 27 years of experience in pharmacology, toxicology, and clinical pathology, Mr. Lindeblad brings extensive scientific and regulatory expertise to preclinical research and program oversight. Throughout his career, Mr. Lindeblad has authored more than 20 scientific publications and abstracts and has contributed to over 300 technical study reports spanning irradiation, acute, subchronic, chronic, and developmental preclinical efficacy and safety studies. His research experience includes radiation and pharmacokinetic (PK) studies across a wide range of laboratory species, including mice, rats, rabbits, dogs, minipigs, hamsters, and non-human primates (NHPs). Mr. Lindeblad has played a leading role in developing radiation models at the University of Illinois at Chicago (UIC) for more than 15 years, including the widely used rabbit model of Acute Radiation Syndrome (ARS). These models have been instrumental in the evaluation of medical countermeasures under BARDA contracts. In addition to his leadership in radiation studies, Mr. Lindeblad has conducted behavioral studies and evaluated cellular therapeutics in both small and large animal models. He served as Study Director on over 75 GLP and non-GLP studies for private industry and federal agencies, including contracts from BARDA, NIH-NCI, and NIH-NIAID. Appointed Laboratory Director in 2019, Mr. Lindeblad now leads facility operations and serves as GLP Management across a wide range of preclinical studies. In this role, he oversees study conduct, ensures compliance with GLP regulations, supports study directors administratively, and maintains coordination across all operational and quality assurance functions. His dedication to scientific rigor and regulatory integrity continues to support the advancement of safe and effective therapies. Outside of work, Matt enjoys spending time outdoors, particularly fishing and exploring new places. He has also coached youth football and baseball for many years, reflecting his passion for mentorship and community involvement.
A distinguished expert in toxicology and preclinical drug development, bringing over 40 years of experience to the field. Throughout his career, he has served as Principal Investigator on numerous government-sponsored programs, collaborating with esteemed organizations such as the NIH, NCI, NIAID, NIDA, BARDA, and DOD. Dr. Lyubimov has pl
A distinguished expert in toxicology and preclinical drug development, bringing over 40 years of experience to the field. Throughout his career, he has served as Principal Investigator on numerous government-sponsored programs, collaborating with esteemed organizations such as the NIH, NCI, NIAID, NIDA, BARDA, and DOD. Dr. Lyubimov has played a pivotal role in advancing preclinical drug development for both emerging biotech firms and leading pharmaceutical companies. As a former Director of TRL and now a trusted Scientific Advisor, he has been instrumental in the development of anticancer therapies, treatments for substance use disorders, anti-AIDS medications, antibiotics, imaging pharmaceuticals, cancer chemoprevention drugs, etc. His expertise also extends to cutting-edge innovations, including anticancer and other nanomaterials and a wide range of biologics for private industry, government agencies, and academic institutions. A recognized leader in regulatory strategy and preclinical research, Dr. Lyubimov participated in preparation of numerous pre-IND and IND submissions to FDA and continues to support TRL as Scientific Director, leveraging his deep industry knowledge to drive scientific advancements. While his passion for research knows no bounds, he also enjoys unwinding with boating/fishing excursions and a spirited game of tennis.
Associate Director and Study Director at UIC-TRL with over 15 years of experience in general toxicology, pharmacokinetics, analytical chemistry, and biomarker assessment. She has a strong interest in translational model development and qualification. Dr. Banerjee has led numerous PK/PD, efficacy, and IND-enabling toxicology studies, as we
Associate Director and Study Director at UIC-TRL with over 15 years of experience in general toxicology, pharmacokinetics, analytical chemistry, and biomarker assessment. She has a strong interest in translational model development and qualification. Dr. Banerjee has led numerous PK/PD, efficacy, and IND-enabling toxicology studies, as well as interdisciplinary drug discovery efforts within a GLP-regulated environment for regulatory submissions. She earned her M.Sc. from Gujarat University and her Ph.D. from Nirma University in Ahmedabad, India. Her research has been featured in over 30 national and international scientific abstracts and publications, and she has presented at various scientific forums. A longstanding member of the Society of Toxicology and the Safety Pharmacology Society, she is passionate about advancing modern medicine. Outside of work, she enjoys cooking elaborate Indian meals, spending time with family, and unwinding with a good book by the fire.
Key member of the UIC-TRL team since 2006, specializing in analytical and bioanalytical method development, validation, and drug/metabolite analysis in biological matrices. He is highly skilled in (ultra)-high performance liquid chromatography and mass spectrometry, ensuring compliance with U.S. FDA GLP regulations. With over 20 years of
Key member of the UIC-TRL team since 2006, specializing in analytical and bioanalytical method development, validation, and drug/metabolite analysis in biological matrices. He is highly skilled in (ultra)-high performance liquid chromatography and mass spectrometry, ensuring compliance with U.S. FDA GLP regulations. With over 20 years of experience in protein biochemistry, molecular cell biology, and (bio)analytical chemistry, Dr. Zakharov has authored more than 30 peer-reviewed publications, presented at international conferences, and contributed professional reports for sponsors. He earned his M.Sc. in Chemistry (Physical Chemistry) and Ph.D. in Biology (Biochemistry) from Moldova State University. He is a member of FEBS, AAPS, ASMS, ACS, and IMA. In his free time, he enjoys mushroom foraging and hiking with family and friends.
Dedicated Supervisor committed to fostering the professional growth of her team and preparing them for successful careers in preclinical research. With over 25 years of GLP experience, she has expertise in all aspects of preclinical study execution across small and large species, radiation research in rodents and larger species, and devel
Dedicated Supervisor committed to fostering the professional growth of her team and preparing them for successful careers in preclinical research. With over 25 years of GLP experience, she has expertise in all aspects of preclinical study execution across small and large species, radiation research in rodents and larger species, and developmental studies in rats and rabbits. She earned her B.S. in Biochemistry from the University of Illinois at Chicago in 2001. In her free time, she enjoys spending time at the Temple and crocheting.
Study Director at TRL-UIC, where he has been a key team member since 2006. With over 30 years of experience in general, neurobehavioral, and reproductive toxicology, as well as PK/PD studies across various species, he is highly skilled in analytical and bioanalytical method development and validation. As a Study Director and Senior Toxico
Study Director at TRL-UIC, where he has been a key team member since 2006. With over 30 years of experience in general, neurobehavioral, and reproductive toxicology, as well as PK/PD studies across various species, he is highly skilled in analytical and bioanalytical method development and validation. As a Study Director and Senior Toxicologist, Dr. Kabirov leads GLP and non-GLP toxicology studies for pharmaceutical discovery and development, including numerous chemopreventive and anticancer agents. Dr. Kabirov earned his M.D. from Perm State Medical Academy and his Ph.D. in Toxicology from St. Petersburg State Medical Academy. He has presented at over 40 national and international conferences and has authored more than 90 abstracts and publications in peer-reviewed journals and books. He is a member of the Teratology Society and the Society of Toxicology.
TOXICOLOGY RESEARCH LABORATORY
808 S Wood St Chicago IL 60612
Copyright © 2025 TOXICOLOGY RESEARCH LABORATORY - All Rights Reserved.
We use cookies to analyze website traffic and optimize your website experience. By accepting our use of cookies, your data will be aggregated with all other user data.